Synthesis and neuropharmacological evaluation of some new isoxazoline derivatives as antidepressant and anti-anxiety agents
نویسندگان
چکیده
منابع مشابه
Synthesis of some new isoxazoline derivatives as possible anti-Candida agents.
The isoxazolines have been reported to possess a variety of significant and diverse pharmacological activities such as antifungal (1, 2), anti-HIV (3), anti-bacterial (4), caspase inhibitory (5), antimuscarinic (6), anti-inflammatory (7), anticancer (8) and anti-depressant (9) activity. On the other hand, the object of antifungal drug discovery has become a subject of greater challenge due to i...
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A series of 5-substituted phenyl-3-(thiophen-2-yl)-4, 5-dihydro-1, 2-oxazoles (2a-l) was synthesized by reacting appropriate chalcones of 2-acetyl thiophene with hydroxylamine hydrochloride in the presence of dry pyridine. The newly synthesized compounds were characterized by IR, HNMR, CNMR and mass spectral data. All the compounds were evaluated for their antidepressant and antianxiety activit...
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Heterocyclic compounds containing a pyrimidine nucleus are of special interests due to their applications in medicinal chemistry as they are the basic skeleton of several bioactive compounds such as antifungal, antibacterial, antitumor and antitubercular. As a part of our research in the synthesis of pyrimidine derivatives containing biological activities, some new tetrahydropyrimidine derivati...
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در این تحقیق روشی جهت سنتز یک سری از کمپلکس های پلاتین (ii) حاوی لیگاند های دهنده ی فسفری شامل فسفیت و فسفین ارائه شده است. واکنش پیش ماده ی پلاتین (ii)،trans/cis- [ptcl2(sme2)2] ، با 2 اکی مولار از لیگاند p(oph)3در حلال بنزن کمپلکس1، cis-[ptcl2(p(oph)3)2] را تولید می نماید. جهت سنتز کمپلکس سایکلو متال فسفیتی، کمپلکس 1 با 1 اکی والان واکنشگر ptcl2 در حلال زایلن در شرایط رفلاکس زیر گاز آرگون م...
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ژورنال
عنوان ژورنال: African Journal of Pharmacy and Pharmacology
سال: 2013
ISSN: 1996-0816
DOI: 10.5897/ajpp2013.3566